ABSTRACT
<b>Objective: </b>Owing to the recent advances in genetic analysis technology, its application in drug development is expected to increase, although there are concerns regarding the leakage of personal information. This study aimed to assess the attitudes of community citizens toward genetic analysis studies associated with clinical trials planned by the pharmaceutical industry.<br><b>Methods: </b>A questionnaire survey was conducted after an educational seminar on drug development at a university campus festival. Answers were obtained from 47 citizens (16 males and 31 females, ages ranging from teens to fifties).<br><b>Results: </b>Attitudes toward providing genome samples were assessed using a 100-mm visual analogue scale, and the data revealed significant differences in the conditions of sample use (A, limited to specific genes during the trial, 89±14 mm; B, limited to genes related to the test drug or target disease, 81±23 mm; C, unlimited, 71±33 mm, <i>p</i><0.01). Twenty-seven citizens (57%) consistently expressed acceptance toward all three conditions. The remaining 38% (<i>n</i>=18) expressed denial as the analysis targets widened. Regarding the acceptable period for sample storage, 17 citizens (36%) allowed “indefinite storage” but 14 citizens (30%) requested “immediate disposal after analysis.” A feedback on the accidental findings of abnormalities was requested by 43 citizens (91%).<br><b>Conclusion: </b>The results demonstrated a wide variety of attitudes toward providing samples. On the other hand, most citizens requested a feedback on the findings of abnormalities for disease-related genes. These results suggest that it is necessary to improve the study protocol to reflect these fears and expectations.
ABSTRACT
Since 1983, we have experienced endovascular treatment of intracranial AVMs.2)3) Superselective catheterization of feeding artery, embolization or feeding artery occlusion of the cerebral AVMs have been performed for 73 cases in 134 sessions. Endovascular treatment of intracranial AVMs such as embolization or feeding artery occlusion have been performed for 57 cases of AVMs in 95 sessions. In each time, endovascular approach was performed for two to five feeding arteries, so more than 300 feeding arteries were catheterized by microcatheters or balloon catheters. In this report, we present our experiences of endovascular treatment of intracranial AVMs and discuss embolic materials and the role of endovascular treatment of intracranial. AVMs.
Subject(s)
Arteries , Catheterization , CathetersABSTRACT
We report a case of a 17-year-old man with subarachnoid hemorrhage (SAH). SAH was from ruptured of an aneurysm of the left middle cerebral artery, for which the clipping was performed. After the surgery, vasospasm was observed by angiographyand the arterial injection of HCI-papaverine was done. A review of the literature is also made.
ABSTRACT
A case of multiple simultaneous intracerebral hematomas is presented. A 80-year-old man who had sudden onset of right hemiparesis and consciousness disturbance was admitted to our hospital. He had a long history of hypertension. A computed tomographic (CT) scan was performed immediately. It demonstrated a left thalamic hemorrhage and a left pontine hemorrhage. No abnormal vessel was recognized on enhanced CT scans, magnetic resonance (MR) images and MR angiography undertaken thereafter. Although he was treated conservatively, his consciousness was not improved after about 2 months of hospitalization. The occurrence of multiple simultaneous intracerebral hematomas is rare in this country. It develops only in a small number of patients who have intraparenchymal hemorrhage. The outcome is poor in the majority of these cases. The prognosis for survival is poor.
ABSTRACT
Metastasis of ovarian malignancy to the central nervous system (CNS) is still rare.<BR>We report a case of a 48-year-old woman with brain metastasis of serous cyst adenocar-cinoma of the ovary as the primary site. Metastasis occurred when postoperative combination chemotherapy and radiation therapy were being given to the patient after complete surgical removal of ovarian tumors. A review of the literature is also made.
ABSTRACT
External decompression was performed on four patients with head trauma and one patient with meningioma. Cranioplasty was done for correcting sknll defeets in these parients later using. Eight ceramic bones. Ceramic bones were made on 3-dimenssional solid models with cranial defects reconstructed based on data of computed tomography scan. The artifical bones conformed to the acutual cranial defects perfectly. Ceramic bone was thought to be suitable for correcting big cranial defects in cosmetic respects. Two complications were observed in these patients during the average follow-up period of ten months. One complication case was infection of artificial bone, and the other was post-operative epidural hematoma. When the size of articial bone was big or the shape of that was strongly curved, we had to pay attention to the tacking of dura during operation.